Previously we showed that Ani (anisodamine)/Neo (neostigmine) combination produced anti-shock effect via activating α7 nicotinic acetylcholine receptor (α7nAChR). In this study, we aim to investigate the therapeutic effect and underlying mechanisms of Ani/Neo combination in acute lethal crush syndrome (CS). In rat and rabbit CS models, Ani/Neo combination increased the 24 h survival rates, improved hemodynamics and decreased the levels of creatine kinase, MB isoenzyme of creatine kinase, blood urea nitrogen, creatinine, K+ in serum. It also decreased the levels of H2O2, myeloperoxidase (MPO) and nitric oxide (NO) in serum and compressed muscle in rat CS model. In wild-type (WT) mice with CS, Ani/Neo combination increased 24 h survival rate and decreased the levels of H2O2, MPO, NO, TNFα, IL-6 and IL-10 in compressed muscle. These effects were attenuated by α7nAChR knockout (KO). Moreover, Ani/Neo combination prevented the decrease of phosphorylation of Janus kinase 2 (JAK2) and phosphorylation of signal transducer and activator of transcription 3 (STAT3) induced by CS. These effects of Ani/Neo in CS mice were cancelled by methyllycaconitine (α7nAChR antagonist) and α7nAChR KO. Collectively, our results demonstrate that Ani/Neo combination could produce therapeutic effects in CS. The underlying mechanism involves the activation of α7nAChR-dependent JAK2-STAT3 signaling pathway.
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How to cite this article: Xu, Z.-Q. et al. Combined administration of anisodamine and neostigmine rescued acute lethal crush syndrome through a7nAChR-dependent JAK2-STAT3 signaling. Sci. Rep. 6, 37709; doi: 10.1038/srep37709 (2016).
The site, called Cruel Onion Wiki, which I noticed had newly appeared in directories of the deep web, collates links to videos of women killing and torturing animals, usually in a sexualised fashion. From rabbits and cats to even a monkey, a pheasant, and some turtles, the creatures are crushed, sat on, or suffocated, often by fully or semi-nude women.
Some of the titles of the videos include "hamster boob crush," "Buttcrush goose and rabbit," and "crush butt mouse 6." You get the idea. In total, there are 103 videos on the site, most of which have additional mirrors, or backups in case the original files get deleted.
For obvious reasons I have not watched the videos on the site, but to confirm the authenticity of the leaked videos, a Motherboard editor watched a portion of a video that was advertised as a woman crushing a rabbit under her heel. According to the editor, it was real, and it was horrifying.
If your rabbit has no sensation in his back legs and no bladder function (your veterinarian can determine this), the most humane decision may be euthanasia. Rabbits with back injuries may need intensive supportive care measures to avoid pressure ulcers and skin damage from urine and fecal soiling. In cases of permanent paralysis, some rabbits can adapt to using a cart to allow movement.
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